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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALK All Species: 19.39
Human Site: T1117 Identified Species: 42.67
UniProt: Q9UM73 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UM73 NP_004295.2 1620 176428 T1117 E V P R K N I T L I R G L G H
Chimpanzee Pan troglodytes XP_001149706 864 91681 P421 T C M D L H K P P G P L V L M
Rhesus Macaque Macaca mulatta XP_001093184 1289 140035 G846 I I A A G G G G R A Y G A K T
Dog Lupus familis XP_540136 1905 205583 T1406 E V P R K N I T L I R G L G H
Cat Felis silvestris
Mouse Mus musculus P97793 1621 174901 T1121 E V P R K N I T L I R G L G H
Rat Rattus norvegicus XP_001067235 1617 174797 T1121 E V P R K N I T L I R G L G H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419364 1584 172486 S1079 E V P R K N I S L I R G L G H
Frog Xenopus laevis Q9PVZ4 1362 153727 S919 V L T P G N Y S V K I R A T S
Zebra Danio Brachydanio rerio XP_691964 1386 150370 A943 L N I A R D I A R G C Q Y L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_652600 1701 185560 Q1194 Q V A R D S L Q L V N A L G K
Honey Bee Apis mellifera XP_392254 1436 158335 M993 D R P T S L R M Q D L I M C G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.2 75.8 78.3 N.A. 87.1 88 N.A. N.A. 69.8 20 42.1 N.A. 28.2 31.3 N.A. N.A.
Protein Similarity: 100 39.5 77 81 N.A. 90.4 90.8 N.A. N.A. 81.1 35.1 54.9 N.A. 42.7 46.5 N.A. N.A.
P-Site Identity: 100 0 6.6 100 N.A. 100 100 N.A. N.A. 93.3 6.6 6.6 N.A. 33.3 6.6 N.A. N.A.
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 100 N.A. N.A. 100 26.6 20 N.A. 60 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 19 19 0 0 0 10 0 10 0 10 19 0 0 % A
% Cys: 0 10 0 0 0 0 0 0 0 0 10 0 0 10 0 % C
% Asp: 10 0 0 10 10 10 0 0 0 10 0 0 0 0 0 % D
% Glu: 46 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 19 10 10 10 0 19 0 55 0 55 10 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 46 % H
% Ile: 10 10 10 0 0 0 55 0 0 46 10 10 0 0 0 % I
% Lys: 0 0 0 0 46 0 10 0 0 10 0 0 0 10 10 % K
% Leu: 10 10 0 0 10 10 10 0 55 0 10 10 55 19 0 % L
% Met: 0 0 10 0 0 0 0 10 0 0 0 0 10 0 10 % M
% Asn: 0 10 0 0 0 55 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 0 55 10 0 0 0 10 10 0 10 0 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 10 10 0 0 10 0 0 0 % Q
% Arg: 0 10 0 55 10 0 10 0 19 0 46 10 0 0 0 % R
% Ser: 0 0 0 0 10 10 0 19 0 0 0 0 0 0 10 % S
% Thr: 10 0 10 10 0 0 0 37 0 0 0 0 0 10 10 % T
% Val: 10 55 0 0 0 0 0 0 10 10 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 10 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _